But even as technologies graduated from dyes to more sophisticated techniques, researchers struggled to trace not only the lineage of cells, but how mature cells related to one another. The idea of lineage tracing-or recording how a single cell gives rise to complex organisms with thousands, millions or trillions of cells-dates back to the 1870s. “But the idea of taking that kind of global view and getting a comprehensive picture of what’s happening during development stayed in the back of my mind for years.” “At the time, I was encouraged to pick a different project that I could actually complete in a reasonable amount of time for my degree,” he says. Problem was, the technology to put that idea into action would not be developed for another decade. Jay Shendure had the notion to put genetic barcodes on cells to track their development when he was just a young graduate student. Cracking the code of developmental biology March 23, 2017
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